Basic Information

Symbol
UBQLN2
RNA class
mRNA
Alias
Ubiquilin 2 Chap1 N4BP4 PLIC2 PLIC-2 Dsk2 Protein Linking IAP With Cytoskeleton 2 Ubiquitin-Like Product Chap1/Dsk2 NEDD4 Binding Protein 4 Ubiquilin-2 CHAP1/DSK2 RIHFB2157 LIC-2 DSK2 Homolog HRIHFB2157 HPLIC-2 ALS15
Location (GRCh38)
X:56563627-56567868
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_013444.4
Sequence length
4242.0 nt
GC content
0.4439

Transcripts

ID Sequence Length GC content
NM_013444.4 NCBI
ACAAGGCGGCGGCGGAGGAGGCCCAGAGACCGGAGCGCGGAGACCUCAG… 4242 nt 0.4439
Summary

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]

Forensic Context

A study in human postmortem brain tissue demonstrated that the UBQLN2 is down-regulated in both the frontal and motor cortices of alcoholic cases compared to controls, as part of widespread changes in the ubiquitin-proteasome system gene expression profile [Liu et al. DOI:10.1111/J.1471-4159.2004.02570.X].