Basic Information

Symbol
UBR5
RNA class
mRNA
Alias
Ubiquitin Protein Ligase E3 Component N-Recognin 5 HYD EDD KIAA0896 EDD1 DD5 E3 Ubiquitin-Protein Ligase, HECT Domain-Containing 1 Hyperplastic Discs Protein Homolog E3 Ubiquitin-Protein Ligase UBR5 Progestin-Induced Protein E3 Ubiquitin Protein Ligase, HECT Domain Containing, 1 HECT-Type E3 Ubiquitin Transferase UBR5 E3 Identified By Differential Display EC 2.3.2.26 EC 6.3.2 HHYD
Location (GRCh38)
8:102250608-102412880
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015902.6
Sequence length
10895.0 nt
GC content
0.4323

Transcripts

ID Sequence Length GC content
NM_001282873.2 NCBI
AGAAGUGAAGAUGGCGGCGGCAGCUUCUCGCUAGUGACGCGCGGUGCGG… 10892 nt 0.4322
NM_015902.6 NCBI
AGAAGUGAAGAUGGCGGCGGCAGCUUCUCGCUAGUGACGCGCGGUGCGG… 10895 nt 0.4323
Summary

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008] CIViC Summary for UBR5 Gene

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the UBR5 in cortical microglia, as part of a broad disruption of the ubiquitin-mediated proteolysis pathway [Oladapo et al. DOI:10.3390/Ijms26020649].