Basic Information

Symbol
UBXN6
RNA class
mRNA
Alias
UBX Domain Protein 6 UBXDC2 UBXD1 UBX Domain-Containing Protein 6 UBX Domain-Containing Protein 1 UBX Domain Containing 1 UBX Domain-Containing 1 UBX Domain-Containing 2 CTB-50L17.16
Location (GRCh38)
19:4444999-4457794
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_025241.3
Sequence length
1915.0 nt
GC content
0.6366

Transcripts

ID Sequence Length GC content
NM_001171091.2 NCBI
AGAGGAGUAUAGGGCUUGAACUGAGAGCCUGGCCUCCCAGAAGGUUUUA… 1816 nt 0.6261
NM_025241.3 NCBI
AUUUUCUUCCGGUGGCUGGUCUCCGGCGGCCCCGUCCCCGACUGGGCCC… 1915 nt 0.6366
Summary

Enables ATPase binding activity. Involved in ERAD pathway; endosome to lysosome transport via multivesicular body sorting pathway; and macroautophagy. Located in bounding membrane of organelle and cytosol. Part of endosome and protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human post-mortem brainstem tissue identified UBXN6 as one of the two most stable endogenous reference genes, alongside SDHA, for RT-qPCR normalization in SIDS and control cases [El-Kashef et al. DOI:10.1007/S12024-015-9717-1]. Using the geometric mean of UBXN6 and SDHA for normalization revealed a statistically significant up-regulation of the target gene RPS27A in SIDS, whereas normalization with unstable single reference genes failed to detect this difference, demonstrating its critical role in generating accurate and reliable gene expression data in forensic molecular pathology investigations.