Basic Information

Symbol
UCP2
RNA class
mRNA
Alias
Uncoupling Protein 2 SLC25A8 Uncoupling Protein 2 (Mitochondrial, Proton Carrier) Mitochondrial Uncoupling Protein 2 Solute Carrier Family 25 Member 8 Dicarboxylate Carrier SLC25A8 BMIQ4 UCPH Body Mass Index Quantitative Trait 4 Body Mass Index QTL 4 UCP 2
Location (GRCh38)
11:73974061-73983542
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003355.3
Sequence length
1644.0 nt
GC content
0.5706

Transcripts

ID Sequence Length GC content
NM_001381943.1 NCBI
ACUGCGAAGCCCAGCUGCGCGCGCCUUGGGAUUGACUGUCCACGCUCGC… 1902 nt 0.5599
NM_001381944.1 NCBI
AGAAACCGUCCUGGCUGGGAAGGCAAGAGGACACAUAGUAUGACCAUUA… 1550 nt 0.5594
NM_001381945.1 NCBI
ACUGCGAAGCCCAGCUGCGCGCGCCUUGGGAUUGACUGUCCACGCUCGC… 1682 nt 0.5713
NM_001381947.1 NCBI
ACUGCGAAGCCCAGCUGCGCGCGCCUUGGGAUUGACUGUCCACGCUCGC… 1761 nt 0.5673
NM_001381948.1 NCBI
ACUGCGAAGCCCAGCUGCGCGCGCCUUGGGAUUGACUGUCCACGCUCGC… 1601 nt 0.5740
NM_001381949.1 NCBI
ACUGCGAAGCCCAGCUGCGCGCGCCUUGGGAUUGACUGUCCACGCUCGC… 1542 nt 0.5739
NM_001381950.1 NCBI
ACUGCGAAGCCCAGCUGCGCGCGCCUUGGGAUUGACUGUCCACGCUCGC… 1449 nt 0.5631
NM_003355.3 NCBI
ACUGCGAAGCCCAGCUGCGCGCGCCUUGGGAUUGACUGUCCACGCUCGC… 1644 nt 0.5706
Summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]

Forensic Context

A study in pediatric burn patients demonstrated that the UCP2 gene expression was significantly upregulated in skeletal muscle following injury, suggesting its involvement in post-burn mitochondrial dysfunction [TzikA et al. DOI:10.3892/ijmm_00000244]. In a mouse model of spinal cord injury, the UCP2 was expressed at higher levels in monocyte-derived macrophages compared to microglia, indicating a cell-type-specific role in the acute inflammatory response [Stewart et al. DOI:10.1186/s12974-021-02161-8]. A study in human pediatric burn patients demonstrated that the UCP2 gene expression was significantly upregulated (P=0.008) in skeletal muscle biopsies taken within 10 days of injury, suggesting its involvement in post-burn mitochondrial dysfunction [Tzika et al. DOI:10.3892/ijmm_00000244].