Basic Information

Symbol
UGT2A1
RNA class
mRNA
Alias
UDP Glucuronosyltransferase Family 2 Member A1 Complex Locus UDP Glucuronosyltransferase 2 Family, Polypeptide A1, Complex Locus UDP Glycosyltransferase 2 Family, Polypeptide A1 UDP-Glucuronosyltransferase 2A1 Uridine Diphosphate Glycosyltransferase 2 Family, Member A1 EC 2.4.1.17 UDPGT 2A1 UDPGT2A1
Location (GRCh38)
4:69588417-69653249
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001252275.3
Sequence length
2653.0 nt
GC content
0.3796

Transcripts

ID Sequence Length GC content
NM_001252274.3 NCBI
ACAUUCGGCUUCUUCCUAAUGUCAAAUGAGUGCUGUUAAAGUUCCUCCA… 3151 nt 0.3723
NM_001252275.3 NCBI
ACAUUCGGCUUCUUCCUAAUGUCAAAUGAGUGCUGUUAAAGUUCCUCCA… 2653 nt 0.3796
NM_001301239.2 NCBI
ACAUUCGGCUUCUUCCUAAUGUCAAAUGAGUGCUGUUAAAGUUCCUCCA… 2521 nt 0.3689
NM_001389565.1 NCBI
ACAUUCGGCUUCUUCCUAAUGUCAAAUGAGUGCUGUUAAAGUUCCUCCA… 3283 nt 0.3744
NM_006798.5 NCBI
ACAUUCGGCUUCUUCCUAAUGUCAAAUGAGUGCUGUUAAAGUUCCUCCA… 2653 nt 0.3717
Summary

The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 infection. [provided by RefSeq, Jan 2022]

Forensic Context

A study in rat primary hepatocytes demonstrated that exposure to 10 ppm lead nitrate for 24 hours induced significant transcriptomic changes, identifying the UGT2A1 as an upregulated molecular hub gene functionally coalescing in critical pathways including bile secretion, chemical carcinogenesis, and cytochrome P450-mediated xenobiotic metabolism [Li et al. DOI:10.1007/S12011-025-04902-9].