Basic Information
Symbol
UGT2B7
RNA class
mRNA
Alias
UDP Glucuronosyltransferase Family 2 Member B7
UGT2B9
3,4-Catechol Estrogen-Specific UDPGT
UDP-Glucuronosyltransferase 2B7
UDP-Glucuronosyltransferase 2B9
EC 2.4.1.17
UDPGT 2B7
UDPGT 2B9
UDPGTh-2
UDP Glucuronosyltransferase 2 Family, Polypeptide B7
UDP Glycosyltransferase 2 Family, Polypeptide B7
UDP-Glucuronyltransferase, Family 2, Beta-7
3,4-Catechol Estrogen Specific
UDPGT2B7
UDPGTH2
UGTB2B9
Location (GRCh38)
4:69051363-69112987
Forensic tag(s)
-
MANE select
Transcript ID
NM_001074.4
Sequence length
1888.0 nt
GC content
0.3941
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GACAGAAAGGAACAGCAACUGGAAAACAAGCAUUGCAUUGCACCAGGAU… | 1888 nt | 0.3941 | |
| GACAGAAAGGAACAGCAACUGGAAAACAAGCAUUGCAUUGCACCAGGAU… | 1668 nt | 0.3855 | |
| AGACAGCUGAGGCAGCCCCUUAGGCAACUUAAGCCUGCCUUGUGGAGUG… | 1480 nt | 0.4372 |
Summary
The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]
Forensic Context
No relevant information is available at the moment.