Basic Information

Symbol
UHMK1
RNA class
mRNA
Alias
U2AF Homology Motif Kinase 1 KIS Kist PAM COOH-Terminal Interactor Protein 2 Serine/Threonine-Protein Kinase Kist U2AF Homology Motif (UHM) Kinase 1 P-CIP2 Kinase Interacting With Leukemia-Associated Gene (Stathmin) Kinase Interacting With Stathmin KIS Protein Kinase EC 2.7.11.1 KIST
Location (GRCh38)
1:162497251-162529631
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_175866.5
Sequence length
8524.0 nt
GC content
0.3741

Transcripts

ID Sequence Length GC content
NM_001184763.1 NCBI
AAGAACUUGUGGAGACCAAAGUUUUGUCAUGCAGAUGAAGCCUCCAGGU… 8194 nt 0.3571
NM_144624.2 NCBI
AUUUCCGGCUUCUGGGACUCGGGUGCACCACGGCUUCCGGUGUCAUGGC… 8446 nt 0.3741
NM_175866.5 NCBI
GGGACUCGGGUGCACCACGGCUUCCGGUGUCAUGGCUGCUUGAAGUCCC… 8524 nt 0.3741
Summary

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Forensic Context

A study in humans identified the UHMK1 as a single-gene blood biomarker, where a machine-learning classifier using 25 genes, which included this biomarker, differentiated healthy controls from methamphetamine-dependent subjects with 87% accuracy [Breen et al. DOI:10.1038/tp.2016.67]. The UHMK1 was specifically implicated in ubiquitin-mediated proteolysis and was previously found as a genetic variant in schizophrenia studies, providing convergent functional genomic evidence for its role in psychosis-related conditions.