Basic Information

Symbol
ULK1
RNA class
mRNA
Alias
Unc-51 Like Autophagy Activating Kinase 1 ATG1 ATG1A Serine/Threonine-Protein Kinase ULK1 Autophagy-Related Protein 1 Homolog EC 2.7.11.1 HATG1 ATG1 Autophagy Related 1 Homolog (S. Cerevisiae) Unc-51 (C. Elegans)-Like Kinase 1 Unc-51-Like Kinase 1 (C. Elegans) ATG1 Autophagy Related 1 Homolog Unc-51-Like Kinase 1 EC 2.7.11 KIAA0722 Unc51.1 UNC51
Location (GRCh38)
12:131894621-131923161
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003565.4
Sequence length
5322.0 nt
GC content
0.6422

Transcripts

ID Sequence Length GC content
NM_003565.4 NCBI
AGUGCGGCUGCGCGGGCGUCUCAGGCUCUGAGGCCCGGGCGCCGCGGCU… 5322 nt 0.6422
Summary

Enables identical protein binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including autophagosome assembly; protein phosphorylation; and regulation of autophagy. Located in bounding membrane of organelle; cytosol; and phagophore assembly site membrane. Part of Atg1 /ULK1 kinase complex. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the ULK1 in cortical microglia, where it is involved in autophagy and mitophagy pathways [Oladapo et al. DOI:10.3390/Ijms26020649].