Basic Information

Symbol
ULK2
RNA class
mRNA
Alias
Unc-51 Like Autophagy Activating Kinase 2 KIAA0623 Unc51.2 ATG1B Serine/Threonine-Protein Kinase ULK2 EC 2.7.11.1 Unc-51 (C. Elegans)-Like Kinase 2 Unc-51-Like Kinase 2 (C. Elegans) Unc-51-Like Kinase 2 EC 2.7.11
Location (GRCh38)
17:19770829-19867937
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014683.4
Sequence length
9149.0 nt
GC content
0.4756

Transcripts

ID Sequence Length GC content
NM_001142610.2 NCBI
AGUCGCGCGGGAGCGGGUAGCGCGCGCGAGGGCGUUGGGCGCCGCCGCG… 3908 nt 0.5366
NM_014683.4 NCBI
AGUCGCGCGGGAGCGGGUAGCGCGCGCGAGGGCGUUGGGCGCCGCCGCG… 9149 nt 0.4756
Summary

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the ULK2 in microglia, implicating it within the autophagy pathway [Oladapo et al. DOI:10.3390/Ijms26020649].