Basic Information

Symbol
UNC5C
RNA class
mRNA
Alias
Unc-5 Netrin Receptor C Unc5 (C.Elegans Homolog) C Protein Unc-5 Homolog 3 Protein Unc-5 Homolog C Netrin Receptor UNC5C UNC5H3 Unc-5 Homolog C (C. Elegans) Unc-5 Homolog 3 Unc-5 Homolog C
Location (GRCh38)
4:95162504-95549206
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003728.4
Sequence length
9642.0 nt
GC content
0.4377

Transcripts

ID Sequence Length GC content
NM_003728.4 NCBI
GUUAUUUCUUCGGACUGCUUCGCGGUGCACGGAUUCAGCUUCUGCCCAG… 9642 nt 0.4377
Summary

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the UNC5C is downregulated in oligodendrocytes in a post-mortem interval (PMI)-dependent manner, indicating its role in cell death regulation [Guo et al. DOI:10.1016/j.ijbiomac.2025.147708].