Basic Information

Symbol
UNG
RNA class
mRNA
Alias
Uracil DNA Glycosylase UNG1 UDG HIGM4 UNG2 DGU Uracil-DNA Glycosylase 1, Uracil-DNA Glycosylase 2 Uracil-DNA Glycosylase UNG15 EC 3.2.2.27 EC 3.2.2 HIGM5
Location (GRCh38)
12:109097572-109126725
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_080911.3
Sequence length
2048.0 nt
GC content
0.5029

Transcripts

ID Sequence Length GC content
NM_003362.4 NCBI
GUGCAGGGUUCCCAGUCACCGCGACGCUCCUCGGGAAGCCAUAGGGCGC… 2093 nt 0.5026
NM_080911.3 NCBI
AAUUGCUGACCGCCACAGCCACAGCCAGGGCUAGCCUCGCCGGUUCCCG… 2048 nt 0.5029
Summary

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]

Forensic Context

A study in rats demonstrated that the UNG mRNA was upregulated at 2 and 24 hours after a 14–15 psi blast exposure, indicating its involvement in DNA repair pathways following severe blast-induced traumatic brain injury [Balaban et al. DOI:10.1016/j.jneumeth.2016.02.001].