Basic Information

Symbol
UPK3B
RNA class
mRNA
Alias
Uroplakin 3B UPIIIb P35 Uroplakin IIIb Uroplakin-3b MGC10902 FLJ32198 UP3B UP3b
Location (GRCh38)
7:76510525-76516522
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001347684.2
Sequence length
2250.0 nt
GC content
0.6373

Transcripts

ID Sequence Length GC content
NM_001347684.2 NCBI
AGCCUGAUUAACCAGCUUCUCCAGGGCCAAGCUGUUGGGGGUGAGGUGC… 2250 nt 0.6373
Summary

UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in mice demonstrated that single-cell RNA sequencing of epicardial-derived cells (EDCs) from a model of arrhythmogenic cardiomyopathy identified distinct cell clusters, including an epithelial cell cluster where the UPK3B was mapped as a transcript marker [Yuan et al. DOI:10.1161/CIRCULATIONAHA.120.052928].