Basic Information

Symbol
UQCRH
RNA class
mRNA
Alias
Ubiquinol-Cytochrome C Reductase Hinge Protein UQCR8 QCR6 Ubiquinol-Cytochrome C Reductase, Complex III Subunit VIII Ubiquinol-Cytochrome C Reductase Complex 11 KDa Protein Cytochrome B-C1 Complex Subunit 6, Mitochondrial Cytochrome C1 Non-Heme 11 KDa Protein Mitochondrial Hinge Protein Complex III Subunit 6 Complex III Subunit VIII MC3DN11
Location (GRCh38)
1:46300900-46316796
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006004.4
Sequence length
537.0 nt
GC content
0.4581

Transcripts

ID Sequence Length GC content
NM_001297565.2 NCBI
CUUCUUGAUCCUGAACUGGGUUAGGUGCCGCUGUUGCUGCUCGUGUUGA… 685 nt 0.4701
NM_001297566.2 NCBI
CUUCUUGAUCCUGAACUGGGUUAGGUGCCGCUGUUGCUGCUCGUGUUGA… 510 nt 0.4569
NM_006004.4 NCBI
CUUCUUGAUCCUGAACUGGGUUAGGUGCCGCUGUUGCUGCUCGUGUUGA… 537 nt 0.4581
Summary

Enables ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrial inner membrane. Implicated in mitochondrial complex III deficiency. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in humans identified the UQCRH as one of the top ten most central mitochondrial-associated genes via protein-protein interaction network analysis in the context of sepsis [Li et al. DOI:10.1186/s12920-024-01891-x].