Basic Information

Symbol
UROD
RNA class
mRNA
Alias
Uroporphyrinogen Decarboxylase EC 4.1.1.37 UPD Uroporphyrinogen III Decarboxylase URO-D PCT
Location (GRCh38)
1:45010950-45015575
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000374.5
Sequence length
1193.0 nt
GC content
0.5549

Transcripts

ID Sequence Length GC content
NM_000374.5 NCBI
AGACAGCUGACCAUGGAAGCGAAUGGGUUGGGACCUCAGGGUUUUCCGG… 1193 nt 0.5549
Summary

This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]

Forensic Context

A study in human patients identified the UROD as a commonly used clinical biomarker for sepsis with rapid and sensitive diagnostic performance for bacterial infection [Leng et al. DOI:10.1186/s12865-025-00702-x].