Basic Information

Symbol
USF1
RNA class
mRNA
Alias
Upstream Transcription Factor 1 BHLHb11 MLTFI UEF Class B Basic Helix-Loop-Helix Protein 11 Major Late Transcription Factor 1 Upstream Stimulatory Factor 1 HYPLIP1 BHLHB11 FCHL1 FCHL MLTF USF
Location (GRCh38)
1:161039249-161045977
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Time since deposition estimation Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_007122.5
Sequence length
1807.0 nt
GC content
0.5440

Transcripts

ID Sequence Length GC content
NM_001276373.2 NCBI
CCUUUUUCAACAUUUUCCUCGGACGCGGUCUUUCCGAGGCUUAUCCAUU… 1760 nt 0.5341
NM_007122.5 NCBI
GCCCCUCACCAACAUGGCCGCGGGCUGGAAGUGCGCAUGAGCAGCUGUC… 1807 nt 0.5440
NM_207005.3 NCBI
GCCCCUCACCAACAUGGCCGCGGGCUGGAAGUGCGCAUGAGCAGCUGUC… 1776 nt 0.5434
Summary

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been defined on chromosome 21. [provided by RefSeq, Feb 2013]

Forensic Context

A study in humans demonstrated that the USF1 exhibits statistically significant rhythmic expression in blood, making it a candidate mRNA marker for estimating blood deposition time [Lech et al. DOI:10.1016/J.Fsigen.2015.12.008]. In a separate human study, the USF1 was highly expressed in the peripheral blood of sepsis patients compared to healthy controls and was expressed in monocyte, NK-T, and B cell lines, with its expression positively correlated with survival rate, indicating its role as a transcription factor correlated with sepsis prognosis [Liu et al. DOI:10.0000000000002072].