Basic Information

Symbol
USP14
RNA class
mRNA
Alias
Ubiquitin Specific Peptidase 14 TGT Ubp6 Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase) Ubiquitin Specific Protease 14 (TRNA-Guanine Transglycosylase) Ubiquitin Carboxyl-Terminal Hydrolase 14 Deubiquitinating Enzyme 14 Ubiquitin Thioesterase 14 TRNA-Guanine Transglycosylase, 60-KD Subunit Ubiquitin-Specific Processing Protease 14 Ubiquitin-Specific-Processing Protease 14 Ubiquitin Thiolesterase 14 EC 3.4.19.12 EC 3.1.2.15
Location (GRCh38)
18:158351-214629
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005151.4
Sequence length
4972.0 nt
GC content
0.3850

Transcripts

ID Sequence Length GC content
NM_001037334.2 NCBI
GAAUGAGACUCGUCGCACCGAAGCCGCCGCCACCACCGCGCCUCCGCCU… 4867 nt 0.3834
NM_005151.4 NCBI
GAAUGAGACUCGUCGCACCGAAGCCGCCGCCACCACCGCGCCUCCGCCU… 4972 nt 0.3850
Summary

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.