Basic Information

Symbol
USP15
RNA class
mRNA
Alias
Ubiquitin Specific Peptidase 15 KIAA0529 UNPH4 Ubiquitin-Specific-Processing Protease 15 Ubiquitin Carboxyl-Terminal Hydrolase 15 Deubiquitinating Enzyme 15 Ubiquitin Thioesterase 15 Ubiquitin Specific Protease 15 Ubiquitin Thiolesterase 15 EC 3.4.19.12 EC 3.1.2.15 UNPH-2 Unph-2 Unph4
Location (GRCh38)
12:62260338-62417431
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001252078.2
Sequence length
14971.0 nt
GC content
0.3633

Transcripts

ID Sequence Length GC content
NM_001252078.2 NCBI
AGUGGAAGAAGAUGGCGGAAGGCGGAGCGGCGGAUCUGGACACCCAGCG… 14971 nt 0.3633
NM_001252079.2 NCBI
AGUGGAAGAAGAUGGCGGAAGGCGGAGCGGCGGAUCUGGACACCCAGCG… 2220 nt 0.3856
NM_001351159.2 NCBI
AGUGGAAGAAGAUGGCGGAAGGCGGAGCGGCGGAUCUGGACACCCAGCG… 16357 nt 0.3621
NM_001351160.2 NCBI
AGUGGAAGAAGAUGGCGGAAGGCGGAGCGGCGGAUCUGGACACCCAGCG… 14822 nt 0.3632
NM_001351161.2 NCBI
AGUGGAAGAAGAUGGCGGAAGGCGGAGCGGCGGAUCUGGACACCCAGCG… 581 nt 0.4561
NM_001351162.2 NCBI
AGUGGAAGAAGAUGGCGGAAGGCGGAGCGGCGGAUCUGGACACCCAGCG… 403 nt 0.3945
NM_001351163.2 NCBI
AGUGGAAGAAGAUGGCGGAAGGCGGAGCGGCGGAUCUGGACACCCAGCG… 15030 nt 0.3637
NM_001351164.2 NCBI
AGUGGAAGAAGAUGGCGGAAGGCGGAGCGGCGGAUCUGGACACCCAGCG… 14969 nt 0.3637
NM_001351165.2 NCBI
AGUGGAAGAAGAUGGCGGAAGGCGGAGCGGCGGAUCUGGACACCCAGCG… 16503 nt 0.3624
NM_001351166.2 NCBI
AGUGGAAGAAGAUGGCGGAAGGCGGAGCGGCGGAUCUGGACACCCAGCG… 15117 nt 0.3636
Showing 1 to 10 of 11 entries
Summary

This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]

Forensic Context

No relevant information is available at the moment.