Basic Information

Symbol
USP19
RNA class
mRNA
Alias
Ubiquitin Specific Peptidase 19 ZMYND9 KIAA0891 Zinc Finger MYND Domain-Containing Protein 9 Ubiquitin-Specific-Processing Protease 19 Ubiquitin Carboxyl-Terminal Hydrolase 19 Ubiquitin Specific Protease 19 Deubiquitinating Enzyme 19 Ubiquitin Thioesterase 19 Ubiquitin Thiolesterase 19 EC 3.4.19.12 EC 3.1.2.15
Location (GRCh38)
3:49108046-49120938
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001199161.2
Sequence length
4721.0 nt
GC content
0.5823

Transcripts

ID Sequence Length GC content
NM_001199160.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4749 nt 0.5923
NM_001199161.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4721 nt 0.5823
NM_001199162.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4685 nt 0.5816
NM_001351098.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4682 nt 0.5824
NM_001351099.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4712 nt 0.5823
NM_001351100.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4752 nt 0.5926
NM_001351101.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4721 nt 0.5819
NM_001351102.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4373 nt 0.5742
NM_001351103.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4418 nt 0.5733
NM_001351104.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4424 nt 0.5735
Showing 1 to 10 of 40 entries
Summary

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

Forensic Context

A study in human blood samples demonstrated that the USP19 was incorporated as one of nine reference genes in the initial primer design for a targeted massively parallel sequencing assay aimed at forensic age estimation, due to its stable expression in blood [Hänggi et al. DOI:10.1016/j.fsigen.2025.103282].