Basic Information

Symbol
USP19
RNA class
mRNA
Alias
Ubiquitin Specific Peptidase 19 ZMYND9 KIAA0891 Zinc Finger MYND Domain-Containing Protein 9 Ubiquitin-Specific-Processing Protease 19 Ubiquitin Carboxyl-Terminal Hydrolase 19 Ubiquitin Specific Protease 19 Deubiquitinating Enzyme 19 Ubiquitin Thioesterase 19 Ubiquitin Thiolesterase 19 EC 3.4.19.12 EC 3.1.2.15
Location (GRCh38)
3:49108046-49120938
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001199161.2
Sequence length
4721.0 nt
GC content
0.5823

Transcripts

ID Sequence Length GC content
NM_001351105.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4599 nt 0.5877
NM_001351106.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4418 nt 0.5738
NM_001351107.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4676 nt 0.5828
NM_001351108.2 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4379 nt 0.5739
NM_001389594.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4755 nt 0.5924
NM_001389595.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4755 nt 0.5920
NM_001389596.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4727 nt 0.5820
NM_001389597.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4458 nt 0.5843
NM_001389598.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4715 nt 0.5822
NM_001389599.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4673 nt 0.5829
Showing 11 to 20 of 40 entries
Summary

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

Forensic Context

A study in human blood samples demonstrated that the USP19 was incorporated as one of nine reference genes in the initial primer design for a targeted massively parallel sequencing assay aimed at forensic age estimation, due to its stable expression in blood [Hänggi et al. DOI:10.1016/j.fsigen.2025.103282].