Basic Information

Symbol
USP19
RNA class
mRNA
Alias
Ubiquitin Specific Peptidase 19 ZMYND9 KIAA0891 Zinc Finger MYND Domain-Containing Protein 9 Ubiquitin-Specific-Processing Protease 19 Ubiquitin Carboxyl-Terminal Hydrolase 19 Ubiquitin Specific Protease 19 Deubiquitinating Enzyme 19 Ubiquitin Thioesterase 19 Ubiquitin Thiolesterase 19 EC 3.4.19.12 EC 3.1.2.15
Location (GRCh38)
3:49108046-49120938
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001199161.2
Sequence length
4721.0 nt
GC content
0.5823

Transcripts

ID Sequence Length GC content
NM_001389600.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4670 nt 0.5827
NM_001389601.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4704 nt 0.5929
NM_001389602.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4746 nt 0.5925
NM_001389603.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4710 nt 0.5930
NM_001389604.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4718 nt 0.5825
NM_001389605.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4565 nt 0.5772
NM_001389606.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4452 nt 0.5847
NM_001389607.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4407 nt 0.5852
NM_001389608.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4412 nt 0.5737
NM_001400288.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 5043 nt 0.5990
Showing 21 to 30 of 40 entries
Summary

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

Forensic Context

A study in human blood samples demonstrated that the USP19 was incorporated as one of nine reference genes in the initial primer design for a targeted massively parallel sequencing assay aimed at forensic age estimation, due to its stable expression in blood [Hänggi et al. DOI:10.1016/j.fsigen.2025.103282].