Basic Information

Symbol
USP19
RNA class
mRNA
Alias
Ubiquitin Specific Peptidase 19 ZMYND9 KIAA0891 Zinc Finger MYND Domain-Containing Protein 9 Ubiquitin-Specific-Processing Protease 19 Ubiquitin Carboxyl-Terminal Hydrolase 19 Ubiquitin Specific Protease 19 Deubiquitinating Enzyme 19 Ubiquitin Thioesterase 19 Ubiquitin Thiolesterase 19 EC 3.4.19.12 EC 3.1.2.15
Location (GRCh38)
3:49108046-49120938
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001199161.2
Sequence length
4721.0 nt
GC content
0.5823

Transcripts

ID Sequence Length GC content
NM_001400290.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4724 nt 0.5821
NM_001400292.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 5009 nt 0.5895
NM_001400293.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 5003 nt 0.5894
NM_001400294.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4706 nt 0.5816
NM_001400295.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4679 nt 0.5826
NM_001400296.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4676 nt 0.5823
NM_001400297.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4964 nt 0.5900
NM_001400298.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4667 nt 0.5828
NM_001400299.1 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4646 nt 0.5822
NM_006677.3 NCBI
GCGCCGGAACCGGAACGGAGAGCGGGUUGCCAGGGCCCGAAGAGGGCUG… 4446 nt 0.5846
Showing 31 to 40 of 40 entries
Summary

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

Forensic Context

A study in human blood samples demonstrated that the USP19 was incorporated as one of nine reference genes in the initial primer design for a targeted massively parallel sequencing assay aimed at forensic age estimation, due to its stable expression in blood [Hänggi et al. DOI:10.1016/j.fsigen.2025.103282].