Basic Information

Symbol
USP25
RNA class
mRNA
Alias
Ubiquitin Specific Peptidase 25 USP21 Ubiquitin Carboxyl-Terminal Hydrolase 25 Deubiquitinating Enzyme 25 Ubiquitin Thioesterase 25 USP On Chromosome 21 Ubiquitin-Specific Processing Protease 25 Ubiquitin-Specific-Processing Protease 25 Ubiquitin Specific Protease 25 Ubiquitin Thiolesterase 25 EC 3.4.19.12 EC 3.1.2.15 EIG19
Location (GRCh38)
21:15729925-15880064
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001283041.3
Sequence length
5379.0 nt
GC content
0.4023

Transcripts

ID Sequence Length GC content
NM_001283041.3 NCBI
AUUCCGGGCGGCCGCUCCCUCCGUCCCCUCUCUCCCUUCCCCAAAGCAG… 5379 nt 0.4023
NM_001283042.3 NCBI
AUUCCGGGCGGCCGCUCCCUCCGUCCCCUCUCUCCCUUCCCCAAAGCAG… 5265 nt 0.4015
NM_001352560.2 NCBI
AUUCCGGGCGGCCGCUCCCUCCGUCCCCUCUCUCCCUUCCCCAAAGCAG… 5419 nt 0.4154
NM_001352561.2 NCBI
AUUCCGGGCGGCCGCUCCCUCCGUCCCCUCUCUCCCUUCCCCAAAGCAG… 5169 nt 0.3985
NM_001388299.1 NCBI
AUUCCGGGCGGCCGCUCCCUCCGUCCCCUCUCUCCCUUCCCCAAAGCAG… 5164 nt 0.4007
NM_001388300.1 NCBI
AUUCCGGGCGGCCGCUCCCUCCGUCCCCUCUCUCCCUUCCCCAAAGCAG… 5041 nt 0.4027
NM_001388301.1 NCBI
AUUCCGGGCGGCCGCUCCCUCCGUCCCCUCUCUCCCUUCCCCAAAGCAG… 5293 nt 0.3994
NM_001388302.1 NCBI
AUUCCGGGCGGCCGCUCCCUCCGUCCCCUCUCUCCCUUCCCCAAAGCAG… 5284 nt 0.3991
NM_013396.6 NCBI
AUUCCGGGCGGCCGCUCCCUCCGUCCCCUCUCUCCCUUCCCCAAAGCAG… 5169 nt 0.4007
Summary

Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in mice demonstrated that the USP25 is an anti-inflammatory factor indicating severe stage, with its peak expression observed in the H06 (late lethal) group during lethal E. coli-induced sepsis [Zhang et al. DOI:10.1093/jimmun/vkaf140].