Basic Information

Symbol
USP9X
RNA class
mRNA
Alias
Ubiquitin Specific Peptidase 9 X-Linked DFFRX FAF-X MRX99 FAF Ubiquitin Specific Protease 9, X Chromosome (Fat Facets-Like Drosophila) Ubiquitin-Specific Protease 9, X Chromosome Ubiquitin Carboxyl-Terminal Hydrolase 9X Deubiquitinating Enzyme FAF-X Ubiquitin Thioesterase FAF-X Fat Facets-Like, X-Linked Fat Facets In Mammals HFAM FAM Ubiquitin Specific Peptidase 9, X-Linked (Fat Facets-Like, Drosophila) Ubiquitin Specific Protease 9, X-Linked (Fat Facets-Like, Drosophila) Probable Ubiquitin Carboxyl-Terminal Hydrolase FAF-X Ubiquitin-Specific Processing Protease FAF-X Ubiquitin-Specific-Processing Protease FAF-X Drosophila Fat Facets Related, X-Linked Fat Facets Protein Related, X-Linked Fat Facets Protein-Related, X-Linked Ubiquitin Thiolesterase FAF-X EC 3.4.19.12 EC 3.1.2.15 MRXS99F XLID99 USP9
Location (GRCh38)
X:41085431-41236579
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001039591.3
Sequence length
12543.0 nt
GC content
0.4104

Transcripts

ID Sequence Length GC content
NM_001039590.3 NCBI
GUUUGCCGGAUCCGCCAUAUUGACGAGGACGGGCAUCCGCGGCUGCGGA… 12591 nt 0.4105
NM_001039591.3 NCBI
GUUUGCCGGAUCCGCCAUAUUGACGAGGACGGGCAUCCGCGGCUGCGGA… 12543 nt 0.4104
NM_001410748.1 NCBI
GUUUGCCGGAUCCGCCAUAUUGACGAGGACGGGCAUCCGCGGCUGCGGA… 12655 nt 0.4105
NM_001410749.1 NCBI
GUUUGCCGGAUCCGCCAUAUUGACGAGGACGGGCAUCCGCGGCUGCGGA… 12607 nt 0.4105
Summary

This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the USP9X was up-regulated in kidney tissue at 8 and 24 hours after whole-body irradiation, with fold changes of 1.906 and 1.839, respectively, as part of the transcriptional/translational response to ionizing radiation [Zhao et al. DOI:10.1158/1078-0432.CCR-05-2418]. In cynomolgus monkeys, chronic exposure to methamphetamine or heroin resulted in the down-regulation of the USP9X in hippocampal tissue compared to controls, as identified through RNA-Seq analysis and validated by RT-qPCR [Choi et al. DOI:10.30773/pi.2022.0004].