Basic Information

Symbol
UST
RNA class
mRNA
Alias
Uronyl 2-Sulfotransferase 2OST Chondroitin Sulfate 2-O-Sulfotransferase CS-2OST Dermatan/Chondroitin Sulfate 2-Sulfotransferase EC 2.8.2.- DS2ST
Location (GRCh38)
6:148746913-149076991
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005715.3
Sequence length
4496.0 nt
GC content
0.4758

Transcripts

ID Sequence Length GC content
NM_005715.3 NCBI
AGAGAAGCCUGAACCGGGACAAAACACGCCGAGACCUACAGACACAAAG… 4496 nt 0.4758
Summary

Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in mice selectively bred for high or low methamphetamine intake identified the UST as a differentially expressed gene overexpressed in the high-drinking line in the ventral midbrain, with this finding overlapping with a prior microarray study [Hitzemann et al. DOI:10.3390/brainsci9070155].