Basic Information

Symbol
UTS2
RNA class
mRNA
Alias
Urotensin 2 U-II UII PRO1068 UCN2 Urotensin II Prepro U-II Urotensin-2
Location (GRCh38)
1:7843083-7853512
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006786.4
Sequence length
591.0 nt
GC content
0.4162

Transcripts

ID Sequence Length GC content
NM_006786.4 NCBI
GAGACAGUUGAAAGUUCUCUACAACAGAAGCCAAGAAGGAAGCCGUCUA… 591 nt 0.4162
NM_021995.2 NCBI
GGGAUGGCAGCCCUAAACACAGCAUGGCAACUCAUCUACUCACUCAUGA… 648 nt 0.4012
Summary

This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human lymphoblastoid cell lines and peripheral blood demonstrated that the UTS2 exhibited significant population differences in expression level, enabling the differentiation of Caucasian and Chinese cohorts with high specificity and sensitivity [Daca-Roszak, P.; Zietkiewicz, E. DOI:10.1007/s13353-019-00510-1].