Basic Information

Symbol
UVRAG
RNA class
mRNA
Alias
UV Radiation Resistance Associated VPS38 UV Radiation Resistance-Associated Gene Protein Beclin 1 Binding Protein P63 UV Radiation Resistance Associated Gene Disrupted In Heterotaxy DHTX
Location (GRCh38)
11:75815180-76144259
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003369.4
Sequence length
5117.0 nt
GC content
0.4606

Transcripts

ID Sequence Length GC content
NM_001386671.1 NCBI
GGUAAUAUGGCUCUUCCUUAGCCAGCGGCGGCAACGGCGGCAGCGGCGG… 5195 nt 0.4610
NM_001386672.1 NCBI
GGUAAUAUGGCUCUUCCUUAGCCAGCGGCGGCAACGGCGGCAGCGGCGG… 4955 nt 0.4607
NM_001386673.1 NCBI
GGUAAUAUGGCUCUUCCUUAGCCAGCGGCGGCAACGGCGGCAGCGGCGG… 3919 nt 0.4116
NM_001386674.1 NCBI
GGUAAUAUGGCUCUUCCUUAGCCAGCGGCGGCAACGGCGGCAGCGGCGG… 1746 nt 0.4588
NM_003369.4 NCBI
GGUAAUAUGGCUCUUCCUUAGCCAGCGGCGGCAACGGCGGCAGCGGCGG… 5117 nt 0.4606
Summary

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.