Basic Information

Symbol
UXT
RNA class
mRNA
Alias
Ubiquitously Expressed Prefoldin Like Chaperone ART-27 STAP1 SKP2 Androgen Receptor Trapped Clone 27 Protein Ubiquitously Expressed Transcript Protein SKP2-Associated Alpha PFD 1 Protein UXT Ubiquitously-Expressed, Prefoldin-Like Chaperone Androgen Receptor Trapped Clone 27 Ubiquitously-Expressed Transcript
Location (GRCh38)
X:47651792-47659187
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004182.4
Sequence length
595.0 nt
GC content
0.5311

Transcripts

ID Sequence Length GC content
NM_004182.4 NCBI
GUCAUUCACCCGCGCCACCCGGAAGCCGCGGUUCCUACCAACCGUUCUU… 595 nt 0.5311
NM_153477.3 NCBI
GUCAUUCACCCGCGCCACCCGGAAGCCGCGGUUCCUACCAACCGUUCUU… 773 nt 0.5524
Summary

The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Forensic Context

A longitudinal mRNA expression analysis in post-mortem human blood samples demonstrated that the UXT shows an up-regulated expression pattern after death and is involved in the establishment of mitochondrion localization, with pathway analysis suggesting active processes promoting cell survival and DNA damage repair are the source of early postmortem gene expression changes [Antiga et al. DOI:10.1038/s41598-021-96095-z].