Basic Information

Symbol
VAMP1
RNA class
mRNA
Alias
Vesicle Associated Membrane Protein 1 VAMP-1 SYB1 Vesicle-Associated Membrane Protein 1 Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1) Spastic Ataxia 1 (Autosomal Dominant) Synaptobrevin 1 Synaptobrevin-1 CMS25 SPAX1 SAX1
Location (GRCh38)
12:6462237-6470677
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014231.5
Sequence length
2736.0 nt
GC content
0.5183

Transcripts

ID Sequence Length GC content
NM_001297438.2 NCBI
AGUAAGUUCCAGCGCAGCUAGACCGCGGGGUAGUCGGCGCGAGGCGGAG… 1219 nt 0.5332
NM_014231.5 NCBI
AGUAAGUUCCAGCGCAGCUAGACCGCGGGGUAGUCGGCGCGAGGCGGAG… 2736 nt 0.5183
NM_016830.4 NCBI
AGUAAGUUCCAGCGCAGCUAGACCGCGGGGUAGUCGGCGCGAGGCGGAG… 1092 nt 0.5321
NM_199245.3 NCBI
AGUAAGUUCCAGCGCAGCUAGACCGCGGGGUAGUCGGCGCGAGGCGGAG… 3139 nt 0.5234
Summary

Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]

Forensic Context

A study in postmortem human brain tissue demonstrated that VAMP1 was downregulated at the RNA level and upregulated at the protein level in subjects with opioid use disorder (OUD) compared to controls [Mendez et al. DOI:10.1038/s41380-021-01259-y]. A study in rats demonstrated that the VAMP1 was part of a cluster of genes whose expression was inversely correlated with injury severity following experimental contusive spinal cord injury [De Biase et al. DOI:10.1152/physiolgenomics.00081.2005].