Basic Information

Symbol
VAMP3
RNA class
mRNA
Alias
Vesicle Associated Membrane Protein 3 CEB Cellubrevin Vesicle-Associated Membrane Protein 3 Synaptobrevin-3 VAMP-3 SYB3
Location (GRCh38)
1:7771296-7781432
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004781.4
Sequence length
2178.0 nt
GC content
0.4229

Transcripts

ID Sequence Length GC content
NM_004781.4 NCBI
GUCCCACCCAUCUCCCUGGCCUCCGGUCCCAACUUCGCUUCUCUGCUGA… 2178 nt 0.4229
Summary

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans and mice demonstrated that VAMP3 was upregulated in whole blood cells and peripheral blood mononuclear cells of patients who developed heart failure after acute myocardial infarction [Chen et al. DOI:10.3389/fimmu.2022.878876].