Basic Information

Symbol
VAMP5
RNA class
mRNA
Alias
Vesicle Associated Membrane Protein 5 Myobrevin Vesicle-Associated Membrane Protein 5 VAMP-5
Location (GRCh38)
2:85584431-85593406
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006634.3
Sequence length
660.0 nt
GC content
0.5909

Transcripts

ID Sequence Length GC content
NM_006634.3 NCBI
ACUGCGGCCGCUCCGCAGGCAGAGAAGCCGGGAGCGGGCGAGGCGGCGG… 660 nt 0.5909
Summary

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of vesicles and cell membranes. The VAMP5 gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family and the SNARE superfamily. This VAMP family member may participate in vesicle trafficking events that are associated with myogenesis. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human postmortem-derived iPSC neurons demonstrated that morphine treatment induced concordant upregulation of the VAMP5 in both the cellular model and ex-vivo brain tissue from individuals with opioid use disorder, validating its dysregulation as part of the opioid exposure response [Mendez et al. DOI:10.3389/Fpsyt.2023.1070556].