Basic Information

Symbol
VASH1
RNA class
mRNA
Alias
Vasohibin 1 KIAA1036 Tubulinyl-Tyr Carboxypeptidase 1 Tyrosine Carboxypeptidase 1 Tubulin Carboxypeptidase 1 TTCP 1 EC 3.4.17.17 Vasohibin-1 VASH
Location (GRCh38)
14:76761468-76783015
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014909.5
Sequence length
6449.0 nt
GC content
0.6006

Transcripts

ID Sequence Length GC content
NM_014909.5 NCBI
GCGGGCCGUAGUCGAGCCUGGUGGGCGGCUGGCUGGCAGGGGACGUGGU… 6449 nt 0.6006
Summary

Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell proliferation; negative regulation of lymphangiogenesis; and regulation of cellular senescence. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human postmortem prefrontal cortex demonstrated that the VASH1 was identified as a high-confidence gene in common between mice and humans within the top 10% of genes related to lifetime alcohol consumption [Farris et al. DOI:10.1038/Mp.2014.159].