Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| AGCACUAGCUGUCGCUCCACAGGCGAGCAGGGCAGGCGUGCGGGCGGGU… | 2826 nt | 0.5690 | |
| AGCACUAGCUGUCGCUCCACAGGCGAGCAGGGCAGGCGUGCGGGCGGGU… | 2796 nt | 0.5647 | |
| AGCACUAGCUGUCGCUCCACAGGCGAGCAGGGCAGGCGUGCGGGCGGGU… | 2892 nt | 0.5657 |
Summary
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
Forensic Context
A study in human forensic autopsy cases demonstrated that RNA sequencing captured molecular signatures associated with specific causes of death, where in a case of fatal anaphylactic shock, the VAV1 was upregulated as a downstream mediator within the FcεRI and T cell receptor signaling pathways [Nakao et al. DOI:10.1016/j.legalmed.2025.102772].