Basic Information

Symbol
VAV2
RNA class
mRNA
Alias
Vav Guanine Nucleotide Exchange Factor 2 Guanine Nucleotide Exchange Factor VAV2 Vav 2 Oncogene VAV-2 Vav 2 Guanine Nucleotide Exchange Factor
Location (GRCh38)
9:133761892-133992854
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001134398.2
Sequence length
4851.0 nt
GC content
0.5673

Transcripts

ID Sequence Length GC content
NM_001134398.2 NCBI
ACUUUGGCUCGAGCACUGCCCUGAGCCGGUCGGGCCCGCGGGCGCCAUG… 4851 nt 0.5673
NM_001411028.1 NCBI
ACUUUGGCUCGAGCACUGCCCUGAGCCGGUCGGGCCCGCGGGCGCCAUG… 4821 nt 0.5683
NM_003371.4 NCBI
ACUUUGGCUCGAGCACUGCCCUGAGCCGGUCGGGCCCGCGGGCGCCAUG… 4734 nt 0.5687
Summary

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly upregulated the VAV2 in oligodendrocytes, where it is associated with the regulation of the actin cytoskeleton pathway [Oladapo et al. DOI:10.3390/Ijms26020649].