Basic Information

Symbol
VAV3
RNA class
mRNA
Alias
Vav Guanine Nucleotide Exchange Factor 3 Vav 3 Guanine Nucleotide Exchange Factor Guanine Nucleotide Exchange Factor VAV3 Vav 3 Oncogene VAV-3
Location (GRCh38)
1:107571161-107965180
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006113.5
Sequence length
5025.0 nt
GC content
0.4384

Transcripts

ID Sequence Length GC content
NM_001079874.2 NCBI
AGUGGUGUUUUACCACUCUGCAGAGAAAGCUAAGGUUGCUAACCAAACA… 3102 nt 0.4104
NM_006113.5 NCBI
AGUGGCGGGCCGGGCGCUGGAGUCGGAAGCCUGUGCGCGGCAGCCGCCG… 5025 nt 0.4384
Summary

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in porcine skin demonstrated that the VAV3 was significantly decreased in all four bromine exposure experimental groups (45 s and 8 min exposures at 24 h and 7 d post-exposure) and was involved in actin cytoskeleton, B cell receptor, Fc epsilon RI, leukocyte extravasation, natural killer cell, and T cell receptor signaling pathways [Price et al. DOI:10.1016/j.toxlet.2008.08.007].