Basic Information

Symbol
VCAN
RNA class
mRNA
Alias
Versican PG-M CSPG2 Chondroitin Sulfate Proteoglycan Core Protein 2 Chondroitin Sulfate Proteoglycan 2 Glial Hyaluronate-Binding Protein Large Fibroblast Proteoglycan Versican Proteoglycan Versican Core Protein GHAP ERVR WGN1 WGN
Location (GRCh38)
5:83471618-83582303
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004385.5
Sequence length
12345.0 nt
GC content
0.4246

Transcripts

ID Sequence Length GC content
NM_001126336.3 NCBI
GCAUUUGAACUUGCAGGCGAGCUGCCCCGAGCCUUUCUGGGGAAGAACU… 4122 nt 0.4326
NM_001164097.2 NCBI
GCAUUUGAACUUGCAGGCGAGCUGCCCCGAGCCUUUCUGGGGAAGAACU… 9384 nt 0.4279
NM_001164098.2 NCBI
GCAUUUGAACUUGCAGGCGAGCUGCCCCGAGCCUUUCUGGGGAAGAACU… 7083 nt 0.4250
NM_004385.5 NCBI
GCAUUUGAACUUGCAGGCGAGCUGCCCCGAGCCUUUCUGGGGAAGAACU… 12345 nt 0.4246
Summary

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Forensic Context

No relevant information is available at the moment.