Basic Information

Symbol
VCL
RNA class
mRNA
Alias
Vinculin Metavinculin VINC MV Epididymis Secretory Sperm Binding Protein Epididymis Luminal Protein 114 Meta-Vinculin HEL114 CMD1W CMH15 MVCL
Location (GRCh38)
10:73995193-74121363
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014000.3
Sequence length
5497.0 nt
GC content
0.4928

Transcripts

ID Sequence Length GC content
NM_003373.4 NCBI
AGUCGCUGCACAGUCUGUCUCUUCGCCGGUUCCCGGCCCCGUGGAUCCU… 6487 nt 0.4785
NM_014000.3 NCBI
AGUCGCUGCACAGUCUGUCUCUUCGCCGGUUCCCGGCCCCGUGGAUCCU… 5497 nt 0.4928
Summary

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Forensic Context

A study in domestic swine demonstrated that vinculin (VCL) is a target of multiple miRNAs and exhibits repression at both transcriptional and post-transcriptional levels in myocardial infarction, with this repression confirmed at the protein level by Western blot [Kaikkonen et al. DOI:10.1161/CIRCGENETICS.117.001702]. The protein marker VINC, investigated in human skeletal muscle, shows degradation products post-mortem and is associated with post-mortem interval (PMI) estimation [Alex et al. DOI:10.1016/j.scijus.2025.101320].