Basic Information

Symbol
VCP
RNA class
mRNA
Alias
Valosin Containing Protein Transitional Endoplasmic Reticulum ATPase CDC48 TERA P97 15S Mg(2+)-ATPase P97 Subunit Valosin-Containing Protein TER ATPase IBMPFD EC 3.6.4.6 HEL-S-70 FTDALS6 HEL-220
Location (GRCh38)
9:35053928-35072671
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_007126.5
Sequence length
3746.0 nt
GC content
0.5144

Transcripts

ID Sequence Length GC content
NM_001354927.2 NCBI
AGUCUCAGCGAAGCGUCUGCGACCGUCGUUUGAGUCGUCGCUGCCGCUG… 3806 nt 0.5187
NM_001354928.2 NCBI
AGUCUCAGCGAAGCGUCUGCGACCGUCGUUUGAGUCGUCGCUGCCGCUG… 4326 nt 0.5460
NM_007126.5 NCBI
AGUCUCAGCGAAGCGUCUGCGACCGUCGUUUGAGUCGUCGCUGCCGCUG… 3746 nt 0.5144
Summary

This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients. [provided by RefSeq, Aug 2017]

Forensic Context

No relevant information is available at the moment.