Basic Information

Symbol
VDAC2
RNA class
mRNA
Alias
Voltage Dependent Anion Channel 2 Non-Selective Voltage-Gated Ion Channel VDAC2 Outer Mitochondrial Membrane Protein Porin 2 Epididymis Secretory Sperm Binding Protein VDAC-2 HVDAC2 POR
Location (GRCh38)
10:75209983-75231456
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001391963.1
Sequence length
1512.0 nt
GC content
0.4431

Transcripts

ID Sequence Length GC content
NM_001184783.3 NCBI
CUCUCAGGCACACAACCCAGCACAGCAAGGCAGUCACACCAAGGCGGUC… 1987 nt 0.4892
NM_001184823.2 NCBI
CUCUCAGGCACACAACCCAGCACAGCAAGGCAGUCACACCAAGAUUCCC… 1412 nt 0.4207
NM_001324087.2 NCBI
CUCUCAGGCACACAACCCAGCACAGCAAGGCAGUCACACCAAGGCGGUC… 1913 nt 0.4867
NM_001324088.2 NCBI
CUCUCAGGCACACAACCCAGCACAGCAAGGCAGUCACACCAAGGCGGUC… 1587 nt 0.4549
NM_001324089.2 NCBI
CUCUCAGGCACACAACCCAGCACAGCAAGGCAGUCACACCAAGGCGGUC… 1691 nt 0.4548
NM_001324090.2 NCBI
CUCUCAGGCACACAACCCAGCACAGCAAGGCAGUCACACCAAGGCGGUC… 1855 nt 0.4911
NM_001391963.1 NCBI
AGAGGACAGGGUUGCGGCGGGCGGAACGGUGUCUCCUUCACUUCGCCCU… 1512 nt 0.4431
NM_003375.5 NCBI
CUCUCAGGCACACAACCCAGCACAGCAAGGCAGUCACACCAAGGCGGUC… 1809 nt 0.4887
Summary

This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Forensic Context

A study in humans and mice demonstrated that the VDAC2 was identified as an apoptosis-related diagnostic marker for sepsis, being downregulated in sepsis patients within the GSE65682 dataset [Sun et al. DOI:10.3389/fgene.2024.1389630].