Basic Information

Symbol
VIPR2
RNA class
mRNA
Alias
Vasoactive Intestinal Peptide Receptor 2 VPAC2R VPAC2 Pituitary Adenylate Cyclase-Activating Polypeptide Type III Receptor Vasoactive Intestinal Polypeptide Receptor 2 Helodermin-Preferring VIP Receptor VIP And PACAP Receptor 2 PACAP Type III Receptor VPAC2 Receptor PACAP-R-3 PACAP-R3 VIP-R-2 C16DUPq36.3 DUP7q36.3 VPCAP2R VIP2R
Location (GRCh38)
7:159028175-159144944
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003382.5
Sequence length
3854.0 nt
GC content
0.5823

Transcripts

ID Sequence Length GC content
NM_001304522.2 NCBI
GCACUCGCUCCCGGCCCAUGCUGGAGGCGGCGGAACCGCGGGGACCUAG… 3614 nt 0.5872
NM_001308259.1 NCBI
AAACUUCACUCCCCAGGGCUCCCAUCCCUGGUGACAAAGAUCACAGCAG… 3788 nt 0.5816
NM_003382.5 NCBI
GCACUCGCUCCCGGCCCAUGCUGGAGGCGGCGGAACCGCGGGGACCUAG… 3854 nt 0.5823
Summary

This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]

Forensic Context

A study in mice demonstrated that the VIPR2 is enriched in a specific oligodendrocyte subcluster within the medial prefrontal cortex of alcohol-dependent subjects [Salem et al. DOI:10.1016/J.Nbd.2023.106361]. In humans, a specific SNP (rs885863) in the 3' UTR of the VIPR2 gene is an expression quantitative trait locus noted in patients with opioid dependence [Reid et al. DOI:10.3390/Ijms231911804].