Basic Information

Symbol
VPS29
RNA class
mRNA
Alias
VPS29 Retromer Complex Component PEP11 DC15 DC7 Vacuolar Protein Sorting-Associated Protein 29 Vesicle Protein Sorting 29 PEP11 Homolog HVPS29 Vacuolar Protein Sorting 29 Homolog (S. Cerevisiae) Epididymis Secretory Sperm Binding Protein Vacuolar Sorting Protein VPS29/PEP11 Vacuolar Protein Sorting 29 Homolog VPS29, Retromer Complex Component Retromer Protein X 007 Protein EC 3.1.3.3
Location (GRCh38)
12:110491083-110502111
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016226.5
Sequence length
1531.0 nt
GC content
0.3906

Transcripts

ID Sequence Length GC content
NM_001282150.2 NCBI
GAGGAGCCUGAGGAAGAGGGCGGCGACGGUGGUGGUGACUGAGCGGAGC… 1686 nt 0.4033
NM_001282151.2 NCBI
GAGGAGCCUGAGGAAGAGGGCGGCGACGGUGGUGGUGACUGAGCGGAGC… 1295 nt 0.3869
NM_016226.5 NCBI
GAGGAGCCUGAGGAAGAGGGCGGCGACGGUGGUGGUGACUGAGCGGAGC… 1531 nt 0.3906
NM_057180.3 NCBI
GAGGAGCCUGAGGAAGAGGGCGGCGACGGUGGUGGUGACUGAGCGGAGC… 1543 nt 0.3927
Summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. [provided by RefSeq, Aug 2013]

Forensic Context

A study in humans identified the VPS29 as a housekeeping gene with highly uniform and strong expression across 16 normal tissue types, including adrenal, adipose, brain, and others, using RNA-seq technology and criteria based on low variance in log2(RPKM) values [Eisenberg and Levanon DOI:10.1016/j.tig.2013.05.010].