Basic Information

Symbol
VPS35
RNA class
mRNA
Alias
VPS35 Retromer Complex Component MEM3 PARK17 Vacuolar Protein Sorting-Associated Protein 35 Maternal-Embryonic 3 FLJ10752 HVPS35 Vacuolar Protein Sorting 35 Homolog (S. Cerevisiae) Vacuolar Protein Sorting 35 Homolog VPS35, Retromer Complex Component Vesicle Protein Sorting 35
Location (GRCh38)
16:46656132-46689518
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_018206.6
Sequence length
6776.0 nt
GC content
0.4169

Transcripts

ID Sequence Length GC content
NM_018206.6 NCBI
ACGCGCGGGGCGGGUGCUGCUUGCUGCAGGCUCUGGGGAGUCGCCAUGC… 6776 nt 0.4169
Summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.