Basic Information

Symbol
VRK2
RNA class
mRNA
Alias
VRK Serine/Threonine Kinase 2 Serine/Threonine-Protein Kinase VRK2 Vaccinia Related Kinase 2 EC 2.7.11.1 Vaccinia Virus B1R-Related Kinase 2 Vaccinia-Related Kinase 2
Location (GRCh38)
2:57907606-58164001
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006296.7
Sequence length
1773.0 nt
GC content
0.3982

Transcripts

ID Sequence Length GC content
NM_001130480.2 NCBI
GUGGACAGGCCGCUGAAAGGAACCGGCUGCGGCCUGUGUGAGGCUCCGC… 1939 nt 0.4146
NM_001130481.2 NCBI
GACGCAGCUGGAGAGAAGUUAGAAGUGAUGCCACCAAAAAGAAAUGAAA… 1781 nt 0.3846
NM_001130482.2 NCBI
GUGGACAGGCCGCUGAAAGGAACCGGCUGCGGCCUGUGUGAGGCUCCGC… 1885 nt 0.4170
NM_001130483.2 NCBI
GUGGACAGGCCGCUGAAAGGAACCGGCUGCGGCCUGUGUGAGGCUCCGC… 1988 nt 0.4120
NM_001288836.1 NCBI
GUGGACAGGCCGCUGAAAGGAACCGGCUGCGGCCUGUGUGAGGCUCCGC… 2076 nt 0.4167
NM_001288837.2 NCBI
AGCAUUUCCAAACAGAGCAACUACAACCACUUCAAACAUCCUAAACUCC… 2509 nt 0.4018
NM_001288838.2 NCBI
AGCAUUUCCAAACAGAGCAACUACAACCACUUCAAACAUCCUAAACUCC… 2440 nt 0.3939
NM_001288839.2 NCBI
CUCGUCGCAGCGGCAGGUAGGAGGCGGUGCGCGCGGCCCGGCGACGGGG… 1703 nt 0.4022
NM_006296.7 NCBI
CUCGUCGCAGCGGCAGGUAGGAGGCGGUGCGCGCGGCCCGGCGACGGGG… 1773 nt 0.3982
Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014]

Forensic Context

A study in humans demonstrated that the VRK2 mRNA was up-regulated by 73% in pericontusional brain tissue from a patient with traumatic brain injury (patient T7) compared to control tissue, as identified via cDNA microarray analysis [Michael et al. DOI:10.1016/j.jocn.2004.11.003].