Basic Information

Symbol
VSNL1
RNA class
mRNA
Alias
Visinin Like 1 VILIP HLP3 Hippocalcin-Like Protein 3 HUVISL1 VILIP-1 HPCAL3 Visinin-Like Protein 1 VLP-1 VISL1
Location (GRCh38)
2:17539020-17657018
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003385.5
Sequence length
2428.0 nt
GC content
0.4012

Transcripts

ID Sequence Length GC content
NM_001366803.2 NCBI
AUACAGAAGGCGCUUGGCUCAGGGUACACAGGGCAAGAAGCCUCGGAUC… 2416 nt 0.4077
NM_001366804.2 NCBI
AAUCUGCAGCAGAGAUUUACCCGAGCGUGUUGCGGCAGCGGCUGGGCUU… 2658 nt 0.4176
NM_001366805.2 NCBI
AAUCUGCAGCAGAGAUUUACCCGAGCGUGUUGCGGCAGCGGCUGGGCUU… 2212 nt 0.3883
NM_001366806.2 NCBI
AAUCUGCAGCAGAGAUUUACCCGAGCGUGUUGCGGCAGCGGCUGGGCUU… 2424 nt 0.4006
NM_003385.5 NCBI
AAUCUGCAGCAGAGAUUUACCCGAGCGUGUUGCGGCAGCGGCUGGGCUU… 2428 nt 0.4012
Summary

This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that VSNL1 was significantly up-regulated across seven brain regions in ethanol-naïve High Drinking in the Dark (HDID-1) mice compared to control mice, with a fold change range of 1.23–1.49, identifying it as a differentially expressed gene associated with a genetic predisposition for binge drinking [Ferguson et al. DOI:10.1007/S12035-018-1252-0].