Basic Information

Symbol
WDPCP
RNA class
mRNA
Alias
WD Repeat Containing Planar Cell Polarity Effector BBS15 CPLANE5 C2orf86 Fritz WD Repeat-Containing And Planar Cell Polarity Effector Protein Fritz Homolog Ciliogenesis And Planar Polarity Effector Complex Subunit 5 Bardet-Biedl Syndrome 15 Protein HFrtz WD Repeat-Containing And Planar Cell Polarity Effector Protein Ciliogenesis And Planar Polarity Effector 5 WD Repeat-Containing Protein C2orf86 Chromosome 2 Open Reading Frame 86 CHDTHP FRITZ HFRTZ FRTZ
Location (GRCh38)
2:63119559-63827843
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015910.7
Sequence length
4894.0 nt
GC content
0.4158

Transcripts

ID Sequence Length GC content
NM_001042692.3 NCBI
AAAUUUUUUAAAUAAAUAGACUGGUAGAGAACACUGAUCAGUAUCCCCU… 4351 nt 0.3909
NM_001354044.2 NCBI
GAUAAGUUGGGACGACCGGACAGCUUCUCAGGUUGCUAAGCGACGAGGC… 5146 nt 0.4153
NM_001354045.2 NCBI
GAUAAGUUGGGACGACCGGACAGCUUCUCAGGUUGCUAAGCGACGAGGC… 2337 nt 0.4810
NM_015910.7 NCBI
GAUAAGUUGGGACGACCGGACAGCUUCUCAGGUUGCUAAGCGACGAGGC… 4894 nt 0.4158
Summary

This gene encodes a cytoplasmic WD40 repeat protein. A similar gene in frogs encodes a planar cell polarity protein that plays a critical role in collective cell movement and ciliogenesis by mediating septin localization. Mutations in this gene are associated with Bardet-Biedl syndrome 15 and may also play a role in Meckel-Gruber syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Forensic Context

A study in humans demonstrated that the WDPCP was downregulated during long-term weight loss (0 to 12 months) in weight losers within subcutaneous adipose tissue [Bollepalli et al. DOI:10.1038/ijo.2017.245].