Basic Information

Symbol
BPIFA2
RNA class
mRNA
Alias
BPI Fold Containing Family A Member 2 SPLUNC2 PSP BA49G10.1 C20orf70 Short Palate, Lung And Nasal Epithelium Carcinoma-Associated Protein 2 BPI Fold-Containing Family A Member 2 Parotid Secretory Protein Chromosome 20 Open Reading Frame 70
Location (GRCh38)
20:33161768-33181412
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_080574.4
Sequence length
1042.0 nt
GC content
0.5115

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-310.50 kcal/mol
Thermodynamic ensemble
Free energy: -328.50 kcal/mol
Frequency: 0.0000
Diversity: 318.59
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((..(((....((((((.((((..((((((((((....(((..((....))..))).....))))))........((....(((((((.(((((.((.........((((((.((((.(((.......))).(((((((((.((.......)).))))).))))..(((((....(.(((((((.(((((..(((...((((((..............(((((((..(((...((((...((((((((((((((.(((......((..((((((((.....))))))))...))....((((((..((((((.((........)).)))))).....)))))).........)))))))))))))))))...))))...))).........)))))))...(((((....((((((((((((..(((......)))..))).....((((...(((.(((.(((((((.((((.(((.....((((((.........)))...)))....)))....)))).))))))).))).)))....)))).....((((......(((.((((.((...(((((.((((...((((......((((((............)))))).....((((((..............))).)))..(((((((.....))))))).....)))))))).))))).)).)))).))).....))))..((((...((((...((((((.....))))))...))))...))))...))))))))).....)))))........))))))))).)))))...))))))).)...((((((.((......((((.(((.(((.(((((...)))))))).))).))))))))))))((((.((.((....)).)).))))............)))))........))))))))))..((((((...............)))))))).)))))..)))))))...))......))))..)))))))))).(((.......)))))).))))).
Thermodynamic Ensemble Prediction
.(((((,,(((..,,(((((.((({(,,((((.{..((((((((...,{,{,({{...{|{,.{((((((.((((...((((....{{,((((((.((((((({(({{.((((({,(((((,((((({(,..((((.{(((((......,)}))).}.)))){{{{{..(((.,......}}|,|}}}}}))))))}}}}}.|||{{{,...{{{((({,,{((,..||||}||,..)),}}))|,}.)))))))))}|.||,,.....{{{((((((((,,{.{||}},}||{.{{{,({{((((((..((((((.((........)).))))))...,.)))))).........(((..{(((((((((((.,,(({((.,{,,(,.......})}.}},...}}))}...|.{((((((((({..,((((......|{{,,|{({{.{{{,,.|.||}..))},,}})))}}|}.}})))))))),}.},,,.)))))))))))),,))).})).}}}.}}).,..|{||,,,..,})..,}}}...{,|||,,.,,...}},,}}}),,||||||||.,..,,,,))))}}}}....((((((............)))))).....,,,.,,..............}}}.)))..{((((((.....)))))))..,)))))}}.....,,,,,))))))..})))))}}.,))))))))...))))))}((((((.....)))))).,,.}}}},}}}}}}}|},}}}.|,......,{(((..........)))).....((((.......)))).,,...)))))))).....((((.(((.(((.(((((...)))))))).))).))))........,{{,.,{,{.....}||.|{||||{....,,,,,....,},))),,..}||{{,|,,,,..((((((....,,...},....))))))...,,,},)}}}.,|||||}}.,,,...)})),,))})))}}}}.(((.......)))}},.))))).

Transcripts

ID Sequence Length GC content
NM_001319164.2 NCBI
AGAAUUUGCAGGGGGGUGACAUCCUCAGACCUGGCCCUUGGCACUGGGA… 1120 nt 0.5125
NM_080574.4 NCBI
AGCAGACUGUGCAGUGGGGCAAGGAUUUCAUGAGCAUCCUCCUCUAAAC… 1042 nt 0.5115
Summary

This gene encodes a member of the palate, lung and nasal epithelium clone (Plunc) family of proteins. Members of this family have been proposed to play a role in the local antibacterial response in nose, mouth and upper respiratory pathways. The encoded soluble salivary protein binds bacterial lipopolysaccharide (LPS) and inhibits bacterial growth. This gene is present in a gene cluster on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Forensic Context

A study in humans demonstrated that the BPIFA2 exhibited a Gini impurity score of 0, being present in all pure saliva samples and in most mixtures containing saliva while being absent in mixtures without saliva, thereby serving as a discriminatory protein for body fluid classification [Shehata et al. DOI:10.1016/j.fsigen.2025.103343].