Basic Information

Symbol
WDR77
RNA class
mRNA
Alias
WD Repeat Domain 77 MEP50 Methylosome Protein 50 P44 WD Repeat-Containing Protein 77 Androgen Receptor Cofactor P44 Methylosome Protein WDR77 P44/Mep50 MEP-50 Testis Tissue Sperm-Binding Protein Li 44a Nbla10071 HKMT1069 WD45
Location (GRCh38)
1:111439890-111449256
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_024102.4
Sequence length
2456.0 nt
GC content
0.4817

Transcripts

ID Sequence Length GC content
NM_001317062.2 NCBI
AGAGGUGCACCACGUGGGGUUUGCUGCCGGAGCGGAGUCUCCGGCCGGC… 2492 nt 0.4823
NM_001317063.2 NCBI
AGAGGUGCACCACGUGGGGUUUGCUGCCGGAGCGGAGUCUCCGGCCGGC… 2450 nt 0.4820
NM_001317064.2 NCBI
AGAGGUGCACCACGUGGGGUUUGCUGCCGGAGCGGAGUCUCCGGCCGGC… 2264 nt 0.4832
NM_024102.4 NCBI
AGAGGUGCACCACGUGGGGUUUGCUGCCGGAGCGGAGUCUCCGGCCGGC… 2456 nt 0.4817
Summary

The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Forensic Context

A study in mice demonstrated that the WDR77 is a protein-coding gene whose promoter region is directly bound by the long non-coding RNA Gm18840 during myocardial ischemia-reperfusion injury, as identified through Chromatin Isolation by RNA Purification sequencing (ChIRP-seq) analysis [Luo et al. DOI:10.3389/fcell.2021.615950].