Basic Information

Symbol
WFIKKN2
RNA class
mRNA
Alias
WAP, Follistatin/Kazal, Immunoglobulin, Kunitz And Netrin Domain Containing 2 WFIKKNRP WFDC20B WAP, Follistatin, Immunoglobulin, Kunitz And NTR Domain-Containing-Related Protein WAP, Kazal, Immunoglobulin, Kunitz And NTR Domain-Containing Protein 2 Growth And Differentiation Factor-Associated Serum Protein 1 WAP Four-Disulfide Core Domain 20B WFIKKN-Related Protein HGASP-1 GASP-1 WAP, FS, Ig, Two KU And NTR Module Related Protein Multivalent Protease Inhibitor Protein GASP1
Location (GRCh38)
17:50834650-50842353
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_175575.6
Sequence length
3417.0 nt
GC content
0.5991

Transcripts

ID Sequence Length GC content
NM_001330341.2 NCBI
GGUGUCCCUGUUUCCUGUACCGUGGUGGGGUAGCUGUGCGACAUGGGCA… 3304 nt 0.5866
NM_175575.6 NCBI
AGAGGCGCCAGCAGCCUGCCUGUGACAGGCAUCAGGUUAGCUGGCUCCC… 3417 nt 0.5991
Summary

The WFIKKN1 protein contains a WAP domain, follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human thoracopagus conjoined twins demonstrated that the WFIKKN2 gene, involved in early growth, was expressed at low levels with a hypermethylated promoter in one twin, as part of integrated multiomics analyses revealing significant local differences in DNA methylation and gene expression related to growth and development [Chen et al. DOI:10.1016/j.rbmo.2023.03.001].