Basic Information

Symbol
WIPI2
RNA class
mRNA
Alias
WD Repeat Domain, Phosphoinositide Interacting 2 CGI-50 ATG18B ATG21 WD Repeat Domain Phosphoinositide-Interacting Protein 2 WIPI49-Like Protein 2 DKFZp686P02188 DKFZP434J154 FLJ12979 FLJ14217 FLJ42984 WIPI-2 WD40 Repeat Protein Interacting With Phosphoinositides 2 IDDSSA
Location (GRCh38)
7:5190182-5233840
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015610.4
Sequence length
4445.0 nt
GC content
0.5379

Transcripts

ID Sequence Length GC content
NM_001033518.2 NCBI
GUACCGGGUGCCCCGGCUCUGGAGCAUAAACAAGAGCGGGGACGGGAUG… 4412 nt 0.5381
NM_001033519.2 NCBI
GUACCGGGUGCCCCGGCUCUGGAGCAUAAACAAGAGCGGGGACGGGAUG… 4358 nt 0.5376
NM_001033520.1 NCBI
ACAGAACUGACUGAAAGGAACCUUUGUCUUUCGUGUGAAUGCUCGUGAG… 4295 nt 0.5276
NM_001278299.2 NCBI
GUACCGGGUGCCCCGGCUCUGGAGCAUAAACAAGAGCGGGGACGGGAUG… 4619 nt 0.5326
NM_015610.4 NCBI
GUACCGGGUGCCCCGGCUCUGGAGCAUAAACAAGAGCGGGGACGGGAUG… 4445 nt 0.5379
NM_016003.4 NCBI
GUACCGGGUGCCCCGGCUCUGGAGCAUAAACAAGAGCGGGGACGGGAUG… 4391 nt 0.5375
Summary

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the WIPI2 in cortical microglia, where it is involved in the autophagy pathway [Oladapo et al. DOI:10.3390/Ijms26020649].