Basic Information

Symbol
WNK1
RNA class
mRNA
Alias
WNK Lysine Deficient Protein Kinase 1 PPP1R167 PRKWNK1 HSAN2 HSN2 Protein Phosphatase 1, Regulatory Subunit 167 Serine/Threonine-Protein Kinase WNK1 Protein Kinase With No Lysine 1 Erythrocyte 65 KDa Protein EC 2.7.11.1 KDP P65 Prostate-Derived Sterile 20-Like Kinase Hereditary Sensory Neuropathy, Type II Serine/Threonine-Protein Kinase WNK1 1 Serine/Threonine-Protein Kinase WNK1 2 Protein Kinase, Lysine Deficient 1 Protein Kinase Lysine-Deficient 1 Kinase Deficient Protein EC 2.7.11 KIAA0344 HWNK1 PSK
Location (GRCh38)
12:752536-911452
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_018979.4
Sequence length
10796.0 nt
GC content
0.4967

Transcripts

ID Sequence Length GC content
NM_001184985.2 NCBI
AGACUCCCGGCGCCAUUUAGCGCGGAGAGUUUCCCGGGUGGACGCGGCU… 11576 nt 0.4932
NM_014823.3 NCBI
AGACUCCCGGCGCCAUUUAGCGCGGAGAGUUUCCCGGGUGGACGCGGCU… 10052 nt 0.4939
NM_018979.4 NCBI
AGACUCCCGGCGCCAUUUAGCGCGGAGAGUUUCCCGGGUGGACGCGGCU… 10796 nt 0.4967
NM_213655.5 NCBI
AGACUCCCGGCGCCAUUUAGCGCGGAGAGUUUCCCGGGUGGACGCGGCU… 11552 nt 0.4941
Summary

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010] CIViC Summary for WNK1 Gene

Forensic Context

A review of human studies summarized that the WNK1 (WNK1) had the most significant increase in expression with age in the Framingham Offspring cohort, identifying it as an aging-associated transcriptome feature [Solovev et al. DOI:10.1016/j.mad.2019.111192].