Basic Information

Symbol
WNK2
RNA class
mRNA
Alias
WNK Lysine Deficient Protein Kinase 2 Serologically Defined Colon Cancer Antigen 43 NY-CO-43 KIAA1760 SDCCAG43 PRKWNK2 Serine/Threonine-Protein Kinase WNK2 Protein Kinase Lysine-Deficient 2 Protein Kinase With No Lysine 2 Antigen NY-CO-43 EC 2.7.11.1 Mitogen-Activated Protein Kinase Kinase Kinase P/OKcl.13 EC 2.7.11
Location (GRCh38)
9:93184122-93320572
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006648.4
Sequence length
7080.0 nt
GC content
0.6648

Transcripts

ID Sequence Length GC content
NM_001282394.3 NCBI
CUCCCCGCGCGCCGGGUCGGAGCCGGUGCGGGAGCGGAGCCGCGCGAAG… 8324 nt 0.6460
NM_006648.4 NCBI
CUCCCCGCGCGCCGGGUCGGAGCCGGUGCGGGAGCGGAGCCGCGCGAAG… 7080 nt 0.6648
Summary

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Forensic Context

A study in rats demonstrated that the WNK2 is downregulated in the medial prefrontal cortex following a history of alcohol dependence, and its expression was restored by treatment with the DNA methyltransferase inhibitor RG-108, identifying it as a convergent target of PRDM2-mediated H3K9me1 and DNA methylation [Heilig et al. DOI:10.1111/Gbb.12344].